Follows people infected with SARS-CoV-2 and their household members to measure initial clinical presentation, viral shedding, transmission, immune response, and ongoing symptoms from the time of infection up to 8 months.

Population:  Children and adults

Partner: University of California, San Francisco (UCSF)

COVID-19 within American Indian Communities at High Risk in the Southwest U.S.

Followed people for up to 12 months who were infected with SARS-CoV-2 to assess the development and duration of symptoms, complications from infection, and immune response over time.

Population: Navajo and White Mountain Apache communities

Partners: Johns Hopkins University, Bloomberg School of Public Health, Center for American Indian Health


COVID: Research on COVID Long-Term Illness, Effects, and Risk Factors (COVID-RELIEF)

Tracks electronic health records of patients who test positive and negative for SARS-CoV-2 and documents symptoms and medical conditions for an average of 2 years after acute infection. A subgroup of patients who previously tested positive for SARS-CoV-2 provides self-reported data on health and biospecimens to investigate genetic and other risk factors for delayed recovery.

Population: Adults receiving care in a university health system

Partner: University of Washington, Seattle, WA

COVID-19: Understanding the Post-Viral Phase (COVID-UPP)

Assesses participants’ health over time using surveys and, for a subset of participants, using physical exams and medical tests to compare differences and similarities of the post-viral phase of SARS-CoV-2 infection with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Adults who tested positive for SARS-CoV-2 and continue to have symptoms more than 3 months after infection are compared with those who fully recovered.

Population: Adults, with a focus on persons who are Hispanic/Latino and who tested positive for SARS-CoV-2 and continue to have symptoms more than 3 months after infection

Partner: Nova Southeastern University, Fort Lauderdale, FL

Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE)

Adults who test positive for SARS-CoV-2 and a comparison group of adults who test negative for SARS-CoV-2 are contacted every 3 months for up to 18 months. Participants complete detailed surveys, including information on social determinants of health, and provide linked electronic health information.

Population: Adults tested for SARS-CoV-2 infection

Partners: Rush University, Yale University, Jefferson Medical, University of Washington, UCLA, UCSF, UT Southwestern, UT Houston


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